The G4 Smooze is briefly mentioned by Twilight in Issue #3. In My Little Pony: Generations, the witches Grackle and Dyre use elements of the G1 Smooze to create hybrid pony creatures ( Violet Shiver, Black Belle, and Shadow Storm) with the power to sow mistrust and hatred between the ponies of Equestria. In My Little Pony: Nightmare Knights Issue #1, the G1 version of the Smooze appears on page 12, and the G4 version appears on pages 13-14. In Between Dark and Dawn, the Smooze appears alongside Discord during Lotta Little Things. In A Royal Problem, he appears having a pillow fight with Discord at the Golden Oak Library's bedroom in a dream bubble as Princess Celestia views the dreams of everyone in Equestria. In What About Discord?, the Smooze appears shrunken in a jar hanging from Discord's neck. His last scene in the episode has him dancing with Pinkie Pie. In the end, Discord apologizes to the Smooze for ignoring him all evening, and the Smooze forgives him. Discord then extracts the valuables from the Smooze's body which returns him to normal size. Tree Hugger suggests that the Smooze needs 'calming auditory therapy', and manages to make him withdraw himself. Twilight and Princess Celestia attempt to use their magic against the Smooze to no avail.

In the second instance, he consumes an entire room of treasures and valuables, causing him to grow to immense size and cover the Gala floor in slime. In the first of these instances, the Smooze eats all the jewels on Rarity's dress. On two occasions, Discord tries to isolate the Smooze from the party so that he can focus on Fluttershy. Throughout the evening, Discord tries to draw Fluttershy's attention away from her new friend Tree Hugger, ignoring the Smooze and the havoc he creates around the Gala ballroom. When Discord and the Smooze first appear at the Gala, Twilight Sparkle worries that their presence will cause trouble, and she warns Discord to keep the Smooze under control. He consumes jewels and other shiny valuables and grows in size whenever he eats. He appears as a sticky green ball of slime, and leaves a trail of slime wherever he moves. His arrival to the Gala is initially met by other Gala guests with gasps of surprise and disgust. The Smooze appears in Make New Friends but Keep Discord as Discord's 'plus-one' to the Grand Galloping Gala. The witches claim that a properly made Smooze cannot be stopped, but they miss some ingredients when making it, and eventually the fluttering of the wings of Flutter Ponies manages to drive back the Smooze. The 1986 Smooze is a grayish purple viscous fluid, and it gradually spreads all over Ponyland. It is concocted by witches who wish to destroy the ponies' idyllic life. The Smooze is based on an identically-named antagonistic entity in the 1986 feature film My Little Pony: The Movie.

The fan smooze